The Small index property for countable 1-transitive linear orders

It is shown that the countable saturated discrete linear ordering has the small index property, but that the countable 1-transitive linear orders which contain a convex subset isomorphic to ${\Bbb Z}^2$ do not. Similar results are also proved in the coloured case

The conjugacy problem for the automorphism group of the random graph

We prove that the conjugacy problem for the automorphism group of the random graph is Borel complete, and discuss the analogous problem for some other countably categorical structures.Comment: 7 page

Countable, 1-transitive, coloured linear orderings I

AbstractWe give a classification of all the countable, 1-transitive, coloured linear orderings for countable colour sets. This is a generalization of Morel's classification of the countable, 1-transitive linear orderings. For finite colour sets, there are ℵ1 examples and for countably infinite colour sets, there are 2ℵ0 (discussed in more detail in a subsequent paper (countable, 1-transitive, coloured linear orderings II, submitted)). We also include a classification of the countable homogeneous coloured linear orders

Countable locally 2-arc-transitive bipartite graphs

We present an order-theoretic approach to the study of countably infinite locally 2-arc-transitive bipartite graphs. Our approach is motivated by techniques developed by Warren and others during the study of cycle-free partial orders. We give several new families of previously unknown countably infinite locally-2-arc-transitive graphs, each family containing continuum many members. These examples are obtained by gluing together copies of incidence graphs of semilinear spaces, satisfying a certain symmetry property, in a tree-like way. In one case we show how the classification problem for that family relates to the problem of determining a certain family of highly arc-transitive digraphs. Numerous illustrative examples are given.Comment: 29 page

The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer

Glucocorticoids (GC) regulate cell fate and immune function. We identified the metastasis-promoting methyltransferase, metastasis-related methyltransferase 1 (WBSCR22/Merm1) as a novel glucocorticoid receptor (GR) regulator relevant to human disease. Merm1 binds the GR co-activator GRIP1 but not GR. Loss of Merm1 impaired both GR transactivation and transrepression by reducing GR recruitment to its binding sites. This was accompanied by loss of GR-dependent H3K4Me3 at a well characterized promoter. Inflammation promotes GC resistance, in part through the actions of TNFα and IFNγ. These cytokines suppressed Merm1 protein expression by driving ubiquitination of two conserved lysine residues. Restoration of Merm1 expression rescued GR transactivation. Cytokine suppression of Merm1 and of GR function was also seen in human lung explants. In addition, striking loss of Merm1 protein was observed in both inflammatory and neoplastic human lung pathologies. In conclusion, Merm1 is a novel regulator of chromatin structure affecting GR recruitment and function, contributing to loss of GC sensitivity in inflammation, with suppressed expression in pulmonary disease

Gendering the careers of young professionals: some early findings from a longitudinal study. in Organizing/theorizing: developments in organization theory and practice

Wonders whether companies actually have employees best interests at heart across physical, mental and spiritual spheres. Posits that most organizations ignore their workforce – not even, in many cases, describing workers as assets! Describes many studies to back up this claim in theis work based on the 2002 Employment Research Unit Annual Conference, in Cardiff, Wales

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries